Index of Applied Science

Blog Index

Aug. 28, 2017 4:40 am
Coupled with automation bias this one is a real doozy. … Pro-innovation bias means that scientists equate new with sexy. Even when those new methods are themselves poorly understood, and there are little data to support their adoption into the mainstream. This is true whether we are talking about a new piece of technology, a new piece of...  Read More
Aug. 23, 2017 6:30 am
Automation bias is the tendency to favour suggestions from automated decision-making systems and to ignore contradictory information made without automation, even if it is correct. And with the growing dependence upon automated methods, it's a problem in laboratories worldwide. To err is human. But to really foul things up, you need a computer. Paul Ehrlich You may...  Read More
Jul. 28, 2017 7:25 am
A Mind at Play: How Claude Shannon Invented the Information Age Jimmy Soni, Rob Goodman New York: Simon & Schuster, 2017 ISBN-10: 1476766681 ISBN-13: 978-1476766683 Curiosity: A Remedy for Dogmatism Every digital device in use today bears the stamp of Claude Shannon's genius. From cell phones to GPS to computers and many other devices, we can experience the contribution that this...  Read More
May 7, 2017 4:54 am
In science, size matters. As a rule-of-thumb, the power to detect true differences - in experimental treatments, between disease groups, in the control and drug arms of a clinical trial - is greater in larger studies. The larger the study the more likely we are to pick up differences larger than can be simply attributable to chance. This is more or less true. Of course, it isn't totally true. ...  Read More
Jun. 5, 2013 10:01 am
Following his excellent nano-technology lecture - at a Skeptics in the Pub meeting - in Nottingham last night, I engaged in some follow-up email correspondence with leading expert Mike Fay of Nottingham University. Mike very kindly answered some questions last night and some more today regarding how much physical space a typical book takes up once scanned and stored electronically. I found the...  Read More
Mar. 2, 2013 1:21 pm
( originally published May 24, 2010 ) Yesterday I attended the first of several graduation parties for my high school senior. This party was for all graduating high school students in our neighborhood – a joint effort that has turned into a wonderful neighborhood tradition. With 21 grads representing three different high schools, each with a different graduation ceremony date, trying to find a...  Read More
Mar. 2, 2013 1:19 pm
( originally published May 14, 2010) A text message arrived the other night from my daughter, a senior in high school, with this question: ‘can we please talk about post-prom plans tonight?’ I applauded her good judgment in granting me a heads up that this was on her mind and needed to be addressed when she returned home later that evening. On the other hand I grumbled internally anticipating...  Read More
Mar. 2, 2013 1:16 pm
( originally published May 3, 2010 ) May 1st has passed, and for many high school seniors a decision that dragged out to the final day is now official. Over the past few weeks I suspect I annoyed my daughter with my questions about which colleges her friends would be attending this fall. So many still seemed to be on the fence. Given my book project, and the rather exaggerated interest I have in...  Read More
Mar. 2, 2013 1:13 pm
( originally published April 26, 2010 ) I just spent a day attending the 21 st annual Writers’ Institute Conference at the University of Wisconsin-Madison. As my book proposal about the college application process continues to take shape, I knew the conference was especially timely. When I first attended it two years ago with a different, and very unfocused book idea, I came away feeling...  Read More
Mar. 2, 2013 12:52 pm
( originally published April 22, 2010 ) Last night was the annual National Honor Society induction ceremony at my daughter’s high school. One year ago, when my daughter was a junior, I was racked with disappointment that our family was not there. She was passed up for admission into the prestigious society after applying in the winter of her junior year. That process was a good warm-up, a...  Read More
Mar. 2, 2013 12:50 pm
( originally published April 13, 2010 ) In last week’s post I suggested that the big college decision facing many high school seniors right now might be blown out of proportion. May 1 st is the usual deadline for most colleges and universities awaiting replies (and deposits) from admitted students, so this can be a critical and somewhat agonizing time for students and their families. While I...  Read More
Mar. 2, 2013 12:44 pm
( originally published April 6, 2010 ) For many households around the country, the past week was monumental as college decision letters (or really, emails) arrived. If you follow The Choice blog on the New York Times website you’ll see endless articles and threads on this topic, and the headlines grabbing the most attention are about the shocking rejections. So many intelligent, gifted...  Read More
Mar. 2, 2013 12:40 pm
( originally published March 29, 2010 ) I spent last Thursday night and Friday traveling with my high school senior to visit the University of Michigan where she’ll be attending school this fall. I couldn’t help but reflect on the differences between this trip and those of last spring when we were on the college tour circuit. As I’ve written about already, those trips were fraught with...  Read More
Mar. 2, 2013 12:37 pm
( originally published March 24, 2010 ) Every time I read Caren Osten Gerszberg’s popular and well-written blog Mom U . , I feel like a bad mom with a dysfunctional daughter. Case in point, in her March 9 th post – On the Road Again, Looking for the Perfect Fit – she talks about the fun and the bonding she and her high school daughter experienced while road tripping to look at college...  Read More
Nov. 5, 2011 7:36 am
The formula for success? It's quite simple, really. Double your rate of failure. Thomas J. Watson Fast Fail strategies work by rapidly clearing the development pipeline of marginal products releasing development resources to focus on more promising products (Lendrem, 1995). The Quick-Kill model demonstrates that Fast Fail strategies will: shorten the expected time to market, even as...  Read More
Oct. 9, 2011 12:13 pm
The Quick-Kill™ model assumes drug discovery is a stochastic process.  The simplest form assumes drug discovery to be a binomial process with probability of discovery p such that the expected number of failures before the first success has a geometric distribution with a mean of 1/ p .  The following discussion considers the simplest case where the development process is divided into...  Read More
Sep. 14, 2011 2:46 pm
Looking for a needle in a haystack? Torching the Haystack: Quick Win, Fast Fail © Dennis Lendrem, 2011  Read More
Aug. 30, 2011 12:11 pm
Futility Theory: The Quick-Kill™ Model : The Quick-Kill™ model assumes drug discovery is a stochastic process. The simplest form assumes drug discovery to be a binomial process w... © Dennis Lendrem, 2011 © Dennis Lendrem, 2011  Read More
Aug. 28, 2011 12:35 pm
"As drug development costs spiral it is worth remembering that only one in 4000 compounds ever reaches the market and it takes around 12 years to develop a new drug. But with a compound capable of grossing US$2 billion per year every day of lost sales costs US$8 million. Not surprisingly then project teams often feel under immense pressure to get a molecule to market as quickly as possible. ...  Read More
Apr. 24, 2011 7:04 pm
Etubics Corporation is experimenting with developing new generation adenoviral-based vectors that can be used in vaccination protocols and other gene delivery approaches. The company's proprietary Adenovirus Vector Vaccine Platform (AVVP) technology can be used to construct gene delivery vectors that can be incorporated in vaccination protocols that require repeat administrations; according to...  Read More
Mar. 20, 2011 7:45 pm
On March 8th 2011, Liquidia Technologies announced that it has received $10 million from the Bill and Melinda Gates Foundation , in order to develop new vaccine candidates utilizing its proprietary PRINT (Particle Replication In Non-Wetting Templates) technology. For those that have been following the activities of the Gates Foundation , it will immediately be evident that this type of...  Read More
Feb. 26, 2011 8:38 pm
Back in July, Immune Design  raised $32 million in a Series B financing; that’s quite a bit of money and brings the total up to $50 million since 2008. Amongst the leading investors we can see ProQuest Investments  (who also have in their portfolio companies like Aerovance , who develops asthma-combating drugs, and   Somalogic , who develops novel diagnostics tools for oncology, neurology and...  Read More
Feb. 26, 2011 8:37 pm
Applying computational approaches to immunogen selection and modification has set new standards in vaccine design. Consider  codon optimization , a method which allowed scientists to circumvent codon usage bias in order to achieve high levels of difficult-to-express proteins outside their native hosts. Codon optimization has helped immensely in the development of HIV prototype vaccines where...  Read More
Jan. 26, 2011 2:46 am
Inovio Pharmaceuticals specializes in creating vaccines with superior characteristics in terms of immunogenicity and T cell responses. At the heart of the company's development pipeline lies its proprietary  SynCon™ DNA Vaccine Platform technology which is described on the company's website as:  "More technically speaking, SynCon™ DNA vaccine antigens are designed by...  Read More
Sep. 20, 2010 2:21 pm
The most dangerous strategy is to jump a chasm in two leaps. - Benjamin Disraeli The second most dangerous strategy is to take the jump in a single leap and almost make it. The third most dangerous strategy is to take the jump in thick fog before you know for sure there is another side to the chasm. A chasm without another side is called a cliff. The fourth most dangerous strategy is to jump...  Read More
Aug. 17, 2010 7:03 am
A very recent Commentary in the Journal of the National Cancer Institute (JNCI) looked into the reasons why despite 25 years of research into biomarkers and high expectations (hope or hype?) this has not translated into success in the clinic (i.e. treatment of cancer). One of problems highlighted was the fact that papers from highly reputable groups/researchers appear to be reviewed in a...  Read More
Mar. 8, 2010 6:03 pm
ERP systems have for the last decade been a profitable business and a big hurdle for companies to climb. Several ERP projects have ended up in a costly mess that has been both delayed and more expensive than expected. The next decade I believe, will not belong to the ERP systems vendors any more. Of course they will have enough work to engage also in the future, I think there is a big change...  Read More
Feb. 1, 2010 7:57 pm
Today I want to point you towards the disruptive nature of the internet, and how it participated in changing the market fundamentally for among others travelling agents, record companys, written media and other business areas. I will focus on the parameter called “ transaction cost ”. Transaction cost I define as the cost of gaining access to what you are in need for. The cost consists of the...  Read More
Dec. 2, 2009 1:22 pm
This thesis immediately raises fierce oppositions. Mildly, they can be treated as questions. Q1. How can this be true as we apparently witness tremendous scientific advancements? A1. What we see are the achievements of technology. A successful technology can be built on a wrong science. For example, the industrial revolution was undertaken regarding heat as a fluid moving in the steam...  Read More
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