Identity Verified Thinker in Business / Industries / Pharmaceuticals
Dennis Lendrem
Dennis Lendrem
MSc in Medical Statistics, PhD from Oxford. Background in Pharmaceutical R&D. Contributor to popular magazines and trade magazines including Scrip Magazine, New Scientist and the Economist. Formerly Editor of the journal Pharmaceutical Statistics.
 
Aug. 31, 2011 1:07 pm
In the late 80's the pharmaceutical industry alighted upon Business Process Re-engineering as a means of increasing development throughput by reducing time to market. In striving to achieve hypothetical minimum time the industry set about re-engineering business processes to maximize development speed . By placing serial development processes into parallel, significant savings were obtained in...  Read More
Aug. 30, 2011 12:11 pm
Futility Theory: The Quick-Kill™ Model : The Quick-Kill™ model assumes drug discovery is a stochastic process. The simplest form assumes drug discovery to be a binomial process w... © Dennis Lendrem, 2011 © Dennis Lendrem, 2011  Read More
Aug. 28, 2011 12:35 pm
"As drug development costs spiral it is worth remembering that only one in 4000 compounds ever reaches the market and it takes around 12 years to develop a new drug. But with a compound capable of grossing US$2 billion per year every day of lost sales costs US$8 million. Not surprisingly then project teams often feel under immense pressure to get a molecule to market as quickly as possible. ...  Read More
Aug. 23, 2011 1:12 pm
Most everything there is to know about project planning is already known. Westheimer's Time Estimation Rule : Estimate the time you think it will take, multiply by 2, and add 3. This rule is independent of the units of time. For example, an individual task you think will take half an hour will take at least two and a half hours. A project you think will take six months will take two and a...  Read More
Aug. 15, 2011 1:27 pm
Write a wise saying and your name will live forever. - Anon Many a scientist dreams of being the first to a new scientific discovery. For their name to live on in the form of an eponymous theory or law such as Newton's Laws or Einstein's Theory. Sadly, it doesn't always work like that. If you want your name to live on you might want to bring in your public relations...  Read More
Aug. 8, 2011 2:42 am
When a reporter asked the bank robber Willie Sutton why he robbed banks he is alleged to have answered "Because that's where the money is." [1] This pithy reminder never to overlook the obvious soon found its way into the medical profession in the form of Sutton's Law. Sutton's Law states that when diagnosing, one should first consider the obvious. It suggests that a physician first conduct...  Read More
Aug. 1, 2011 1:30 pm
Goodhart's Law can be thought of as an economic, organizational or behavioural variation on the Heisenberg Uncertainty Principle. Goodhart's Law states that: "Any observed statistical regularity will tend to collapse once pressure is placed upon it for control purposes." Alternatively: "once a measure is made a target for the purpose of conducting policy, then it will lose the information...  Read More
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