Leo Depuydt was born and grew up in Flanders, Belgium. He studied Greek, Roman, and other early civilizations at the Catholic University of Leuven, the Hebrew Union College in Cincinnati, the Hebrew University of Jerusalem, and the Eberhard Karls University in Tübingen, and briefly worked and lived at a Benedictine abbey in Bruges before completing his doctoral work at Yale (1985–1990), where he also taught as Senior Lector in Coptic and Syriac (1989–1991).

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The Other Mathematics: Language and Logic in Egyptian and in General (Piscataway, New Jersey: Gorgias Press 2008).

He has authored, or co-authored as editor, thirteen books and written about 125 articles and about 50 reviews on topics relating to ancient and medieval manuscripts, languages, and history, with primary focus on ancient Egypt. Among his current projects are monographs in preparation that are entitled Digitalizing Thought: Boolean Essays in Language and Probability, The Meaning of "Meaningless" Preterit pe in Coptic Egyptian, and The Commencement of the Common Era: Panodoros’ World Era, Dionysius’ Incarnation Era and Why A.D. 1 is A.D. 1.

He has been at Brown University since 1991, teaching in its Department of Egyptology, which was reconstituted in 2005 as the Department of Egyptology and Ancient West Asian Studies to reflect a wider focus on the origins of science and the humanities in the ancient Near East.

Dr. Depuydt is currently working on a piece entitled "How the Biological Brain Reasons: The Four Digital Operations Underlying All Rational Thought and Language." It is expected to be published in the summer of 2010.